• Do You Have A Warrior Or Worrier Gene?

    Why some people cope better with stress and some fold under the pressure? This can be explained with COMT gene. It is one of the most important markers associated with intelligence and personality. COMT gene codes for the COMT enzyme which breaks down dopamine in the prefrontal cortex. This is the part of the brain that is responsible for planning, decision making, cognitive ability, problem-solving, reasoning. COMT gene marker (SNP) has two alleles. Please remember that this one marker does not define You as a person thou, but is related to the statistical findings.

  • Diabetes Type 2

    Type 2 diabetes usually develops later in life and is a metabolic disorder often caused by lifestyle, which you can prevent if you learn about the genetic relations with the disease. Type 1 diabetes usually develops in early childhood and adolescence and is an autoimmune disorder.

  • Umami – the 5th taste. Do You have it?

    There is a variation in umami tasting sensitivity among different individuals. The umami taste is elicited by glutamate (an amino acid) in foods. Glutamate interacts with the taste receptors and a sensation of umami is the result. There are several taste receptor genes, each gene produces a part of the taste receptor. The umami receptor is made up of two parts. It has been found that a variant SNP in one gene, TAS1R3, that produces one part of the umami receptor, may double umami tasting sensitivity. This variant is the relatively rarer T allele…

  • Do You Age Faster Because Of The Sun?

    Photoaging is premature aging of the skin caused by ultraviolet (UV) radiation from the sun and artificial sources. It is associated with the SNP in genes STXBP5L and FBXO40. This marker has two alleles, A and G. The G allele is the risk allele associated with more severe photoaging. The A : A genotype on the other hand is associated with less severe photoaging.

  • Folate metabolism and genetics

    Folate is a generic name for both natural and synthetic forms of the B9 vitamin, such as folic acid, folinic acid and 5-methyltetrahydrofolate.

    Folate metabolism and genetics are related. To view related SNPs please login or purchase subscription to compare it with your genetic data…

  • Breast Cancer Prevention – Self Control

    October is breast cancer awareness month! Because of the seriousness of the cancer  type there is a need for every lady for self examination which helps to discover the cancer as soon as possible. Luckily the procedure of self examination is quite easy and everyone can do it right at home.

    The examination procedure consists of 5 steps:

  • NSAID drug metabolism

    Impaired NSAID drug metabolism is believed to be caused by several genes. To assess the risk of having an impaired NSAID metabolism, these genes are grouped into a set called genoset. If you have a risk genoset then it means you have 3x higher risk for developing gastrointestinal bleedings or ulcers during treatment with NSAIDs. In this case, enzymes responsible for the clearance of NSAIDs are impaired, which causes gastrointestinal toxicity resulting in ulcers and bleeding.

    NSAIDs used in Estonia and internationally:

    Salicylates (Aspirin, Diflunisal, Salicylic acid, Salsalate)
    Propionic acid derivatives (Ibuprofen, Dexibuprofen, Naproxen, Fenoprofen, Ketoprofen, Dexketoprofen, Flurbiprofen, Oxaprozin, Loxoprofen)
    Acetic acid derivatives (Indomethacin, Tolmetin, Sulindac, Etodolac, Ketorolac, Diclofenac, Aceclofenac)
    Enolic acid derivatives (Piroxicam, Meloxicam, Tenoxicam, Droxicam, Lornoxicam)
    Coxibs (Celecoxib, Rofecoxib, Valdecoxib, Parecoxib, Etoricoxib, Lumiracoxib)
    Fenamates (Mefenamic acid, Tolfenamic acid, Flufenamic acid, Meclofenamic acid)

    If you have a risk genoset, then you should consult with your doctor about which NSAIDs to use and in what doses. NSAIDs can also increase bleeding through decreasing the ability of blood to clot. Therefore, people who are taking drugs that also increase bleedings, such as Warfarin, should avoid prolonged use of NSAIDs. Also, patients with rheumatoid arthritis are at high risk for developing gastrointestinal bleedings because of the prolonged use of NSAIDs.