Photoaging is premature aging of the skin caused by ultraviolet (UV) radiation from the sun and artificial sources. It is associated with the marker rs322458 and the genes STXBP5L and FBXO40. This marker has two alleles, A and G. The G allele is the risk allele associated with more severe photoaging. The A : A genotype on the other hand is associated with less severe photoaging.

A : A
Less severe photoaging

A : G
More severe photoaging

G : G
More severe photoaging


Photoaging manifests mainly as sagging and wrinkling of the skin. Pigmented spots such as freckles and lentigines may appear. Photoaging usually occurs on the most exposed areas of the body – face, neck and hands.

Photoaging is caused by extrinsic or environmental factors. The main factor is sun exposure. UV radiation from the sun has several damaging effects on the skin. It causes mutations in the DNA and forms reactive oxygen species (ROS). Furthermore it causes the degradation of collagen and other important structural features of the skin.

Read more about DNA damage from here!


The main method of protecting your skin from photoaging is sunscreen. Sunscreens work by blocking or absorbing UV radiation. A proper sunscreen should protect against both UVB and UVA radiation. Antioxidants protect the skin from damaging effects of free radicals. They decrease wrinkles and increase collagen, which is an important structural protein in the skin.

Topical solutions should be used, as oral intake does not result in increased levels in the skin. Retinoids are synthetic derivatives of vitamin A. Vitamin A and retinoids increase collagen production and inhibit some negative effects of UV radiation. Retinoids can be found in many skin creams and lotions.

People with genotypes G : G and G : A should take extra caution. Exposure to sun and to artificial sources of UV radiation (e.g. tanning beds) should be limited. Meticulous application of sunscreen is necessary. It should be noted that clouds do absorb some but not all UV radiation. Use of topical antioxidants and retinoids can be considered.

Even though people with the genotype A : A do experience less severe photoaging, UV radiation still has a damaging effect on their skin as well. Use of sunscreen and limiting excess exposure to sun and to artificial sources of UV radiation (e.g. tanning beds) is still necessary.


*Canadian Dermatology Association Photoaging. ( Retrieved 06.07.18 Le Clerc, S., Taing, L., Ezzedine, K., Latreille, J., Delaneau, O., Labib, T., Coulonges, C., Bernard, A., Melak, S., Carpentier, W., et al. (2013).

*A Genome-Wide Association Study in Caucasian Women Points Out a Putative Role of the STXBP5L Gene in Facial Photoaging. Journal of Investigative Dermatology 133, 929–935.

*Rafieepour, A., Ghamari, F., Mohammadbeigi, A., and Asghari, M. (2015). Seasonal Variation in Exposure Level of Types A and B Ultraviolet Radiation: An Environmental Skin Carcinogen. Annals of Medical and Health Sciences Research 5, 129–133.

*Rosi Helfrich, Y., Sachs, D., and J Voorhees, J. (2008). Overview of skin aging and photoaging.

Updated: 07.07.2018
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